Introduction

PyClone is a probabilistic model for inferring clonal population structure from deep NGS sequencing. PyClone is a Bayesian clustering method for grouping sets of deeply sequenced somatic mutations into putative clonal clusters while estimating their cellular prevalences and accounting for allelic imbalances introduced by segmental copy-number changes and normal-cell contamination. Single-cell sequencing validation demonstrates PyClone's accuracy.

For more information about PyClone, visit the PyClone official website.

Programming language: Python

Brief description: PyClone is a probabilistic model for inferring clonal population structure from deep NGS sequencing.

Open-source license: View license